abberior news

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Tracking of biomolecules: MINFLUX at its best!

Would you like to learn more about cutting edge tracking?

Have a look at these two independent publications on MINFLUX tracking of motor proteins kinesines moving along microtubules.
Congratulations to @JonasRies Lab, @Stefan_W_Hell and @StefanHellLabs.

Publications

Jan O. Wolff, et al.: “MINFLUX dissects the unimpeded walking of kinesin-1”, bioRxiv (2022)
Details >

Takahiro Deguchi, et al.: “Direct observation of motor protein stepping in living cells using MINFLUX”, bioRxiv (2022)
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Stefan Hell is admitted to the Order Pour le mérite

The admission is one of the highest honors for scientists and artists in Germany.

The order Pour le mérite admits Stefan Hell. Admission to the Order is one of the highest honors that can be bestowed on a scientist or artist in Germany. The first chancellor of the order was the naturalist Alexander von Humboldt.

Congratulations to our co-founder Stefan Hell on his acceptance into the Order Pour le mérite.

“Admission to the Order is one of the highest honors that can be bestowed on a scientist or artist in Germany. The association of artists and scholars was founded in 1842 by Prussian King Frederick William IV and revived in 1952 by German Bundespräsident Theodor Heuss. It is under the protectorate of the Bundespräsident. The first chancellor of the order was the naturalist Alexander von Humboldt.” BPA, 22.07.2022

Press releases:

Presse- und Informationsamt der Bundesregierung (BPA)
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Max-Planck-Institut, Göttingen
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3D MINFLUX image of protein bassoon in rod photoreceptor synapses prepared using Heat Assisted Rapid Dehydration (HARD). The z-coordinate is color-coded to highlight the two parallel rows of molecules surrounding the active site.

Scientists at the Institute for Auditory Neuroscience, UMG, the Max Planck Institute for Multidisciplinary Sciences and abberior instruments apply high-resolution 3D-MINFLUX technology for precise 3D representation of the molecular organization in the active zone of rod photoreceptor cells. Published in Science Advances.

Press release UMG

Publication Science Advances

 

abberior team on fire at 32. Goettinger Altstadtlauf 2022

Running is a lot of fun for everyone: This becomes clear at the 32. Göttinger Altstadtlauf. After a two-year break from the Corona, several thousand athletes start the race. The abberior running team participated in the Company Cup this year.
We were not aiming to be the first to cross the finish line 🙂  It was about being strong together as a team, achieving something together, having fun, and toasting our achievement with a smile on our faces at the end.

This is a wonderful team spirit!

Live-cell fluorescence microscopy is an indispensable tool in biomedical and biophysical research, allowing the study of dynamic processes in living systems. We are excited to present our new copper-free clickable dyes, a minimal-sized tag for biorthogonal live-cell labeling.

Our new abberior LIVE click tetrazine-based probes expand the toolbox of super-efficient organic dyes for multicolor live-cell imaging. Specific labeling of intracellular targets using abberior LIVE probes for DNA, actin, tubulin, SNAP, click, and STAR membrane, making long-term live-cell imaging at extremely low nanomolar probe concentrations possible.

This unique combination of tags takes live-cell imaging to the next level and will make super-resolution imaging of living systems a routine, easy-to-use visualization method and paves the way for a deeper understanding of the nanoarchitecture of life.

Do you often wonder what strategies are available to optimize your multicolor STED experiment?

Listen to our speakers Elisa D’Este, head of the optical microscopy facility at the MIP for medical research, and Florian Grimm Business Developer at abberior. See how different labeling techniques like indirect immunofluorescence, nanobodies, direct labels, membrane probes, or self-labeling enzymes can be combined to achieve colorful images at the highest resolution in living or fixed samples.

Watch the recording of our last webinar on July 7, 2022, 15:00 (CEST)

Celebrating the completion with traditional German toast and ornament
abberior co-founders Prof. Hell (Nobel prize laureate), Dr. Egner (Head of IFNANO), Dr. Donnert (CEO)
Jens Düwel, CEO of GWG, urban business developer, funding the project welcoming guests
With its seven stories, abberior's new headquarters is hard to miss

In November last year we celebrated the foundation laying ceremony for abberior’s new headquarters. The new building is being constructed at Göttingen’s North Campus in the direct vicinity of our founding location and previous HQ under the roof of IFNANO. In addition, the Max Planck Institute for Multidisciplinary Sciences (MPI-NAT), a close partner in research, is not far away as well. The proud construction workers were joined by abberior’s founding team, the organizers behind the new building, and the new head mayor of Göttingen, Petra Broistedt, to celebrate the occasion. In her speech on the occasion, she emphasized how important abberior and its contribution to the further development of the world of microscopy is both for researchers worldwide and for Göttingen as a location.

Now it won’t be long until the grand opening and the relocation. We are already excited!

Until then, we will keep you up to date with the progress on our social media pages (Twitter, Instagram, LinkedIn, Facebook). And while you’re at it: Why not have a look at our current job postings and save yourself a seat in our new headquarters?

Richtfest für neues Laborgebäude von GWG und Abberior am Nordcampus (Göttinger Tageblatt, in German, 28.04.2022) >

abberior Faktum article 2022-01

“Invented, developed and built in Göttingen: Thanks to the discovery of Nobel laureate Stefan Hell, scientists around the world are seeing things through abberior microscopes that they have never seen before – and can achieve decisive breakthroughs in research.”

Read the article as PDF >
Read the article online >

Explore abberior’s new lifetime toolbox TIMEBOW with Julia & Gero. See how lifetime and STED super-resolution imaging come together easily with our phasor-based tools. MATRIX detection adds unique lifetime imaging modes and extra clarity to the mix.

We are very pleased to announce that our founder Prof. Stefan Hell will meet you online next Thursday at iCANX SUMMIT 2022. He will introduce the revolutionary localization principle MINFLUX and present his latest imaging technology MINSTED.

You can click here > or scan the QR code to watch the talk online.

Title of talk:MINFLUX and MINSTED enable molecule-level resolution in fluorescence microscopy.
Date and time: Thursday, April 28, 2022, 2:00 PM (CEST).

Live-cell fluorescence microscopy is an indispensable tool in biomedical and biophysical research, allowing the study of dynamic processes in living systems. We are excited to present our new membrane dyes, that visualize the plasma membrane of living cell!

abberior STAR membrane probes profit from a special linker designed to minimize the impact on the membrane to maintain the overall mobility and diffusivity. Try the new abberior method of cell membrane labeling. In combination with our abberior LIVE dyes, you get a toolbox of super-efficient probes, that provide specific labeling of intracellular targets and outer cell membrane, making long-term live-cell imaging at extremely low nanomolar probe concentrations possible.

This unique combination takes live-cell imaging to the next level and will make super-resolution imaging of living systems a routine, easy-to-use visualization method, paving the way for fundamental biological discoveries.

abberior's MINFLUX system at EMBL Imaging Centre, Heidelberg

The EMBL Imaging Centre and abberior Instruments GmbH extend their collaboration. After a successful first phase of three years, both parties agreed to continue the joint development of technology and applications for the next generation MINFLUX.
MINFLUX is the latest breakthrough in light microscopy, capable of observing biological structures with unprecedented temporal and spatial resolution. A particularly exciting area for groundbreaking biological applications is the structural biology of living systems. Here, the envisioned unique benefit of MINFLUX will be to observe the critical conformational changes in real-time at the nanoscale that allow molecular machines to perform their function.

EMBL Imaging Centre:
With 27 member states, the European Molecular Biology Laboratory (EMBL) currently employs more than 1800 people with more than 110 independent research groups and service teams covering the spectrum of molecular biology at six sites in Barcelona, ​​Grenoble, Hamburg, Heidelberg, EMBL-EBI Hinxton, and Rome. The EMBL Imaging Centre is the latest addition to the EMBL headquarters in Heidelberg. It offers the most advanced high-resolution electron and light microscopy technologies, including new and in-house developed methods that are not yet commercially available. The EMBL Imaging Centre builds on EMBL’s strength in imaging technology development and nearly five decades of experience in world-class service provision for life science research. This will encompass external access to novel, cutting-edge superresolution technology, which includes MINFLUX technology, in both commercial and pre-commercial configurations and performance. Each year up to 150 visiting scientists will be able to visit the new center to access the very latest imaging technologies. EMBL’s highly qualified experts will provide the visitors with tailored support from sample preparation to data analysis. An additional aim of the center is to develop the next generation of imaging technologies for life science applications in close cooperation with industrial partners.

abberior Instruments:
abberior Instruments and it’s sister company abberior were founded in 2012 as spin-offs of the Max-Planck Institute for Biophysical Chemistry in Göttingen and the German Cancer Research Center in Heidelberg. The mission of the founders around Nobel laureate Prof. Dr. Stefan Hell is to make groundbreaking developments in high-resolution light microscopy available to biological and medical researchers. The focus is on both rapid implementation and, at the same time, simple and broad applicability. Numerous awards, including the TOP100 Innovation Award 2021, the Innovation Award of German Science, and the Focus Growth Champion 2019, highlight the success of the abberior group. Meanwhile, abberior Instruments has offices in Europe, America, and Asia and has put up hundreds of microscopes in more than 30 countries with 100 very talented people working all around the globe.

This short video covers fluorescence lifetime analysis and separation using phasor plots with confocal and STED super resolution. Additionally, Julia and Gero demonstrate background subtraction with MATRIX and they show how to achieve high resolutions at only 2% STED laser power using lifetime data.

Lifetime imaging was never so easy and TIMEBOW and MATRIX array detection are a winning combination – only available from abberior. See for yourself!

abberior, the leading provider of STED and MINFLUX super resolution microscopes, announces a new strategic partnership with OptoFeM. This cooperation empowers both parties to deliver the highest levels of quality, service, and application support covering whole Abberior Instruments product portfolio to customers in China.

The collaboration already started in 2019 and is now lifted to the level of strategic partnership, being developed into a highly intensive, large-scale collaboration in the fields of application support, sales, and service.

“We are very happy to work so efficiently, seamlessly and successfully together with our partner OptoFeM. We are jointly accelerating the adoption of our abberior super resolution technology, and we can feel that our brand is getting high traction in China. It is very fascinating to see how quickly and professional scientific research is developing there. Our quality and the abberior super resolution performance is highly appreciated by our customers in China.” says Dr. Gerald Donnert, CEO of abberior Instruments GmbH.

“OptoFeM and abberior have joined hands in strength and in-depth cooperation. Relying on abberior’s outstanding optical imaging products and OptoFeM’s sound sales and service system together we are developing the Chinese optical imaging market. We look forward to providing more outstanding products and service to Chinese customers.” says Mr. Qi Dong, CEO of OptofeM.

Congratulations to our founder Stefan Hell, who shares the Werner-von-Siemens Ring 2022 with the main scientific forces of BioNTech, Uğur Şahin, Özlem Türeci, Christoph Huber and Katalin Karikó.

Stefan is honored for being the first to show that the diffraction barrier of light microscopy can be broken. His STED microscopes achieve resolutions up to 20 nm, about a hundred times sharper than conventional instruments. Other physicists soon realized the potential of the principle and developed similar techniques. Together, these quickly arrived in life science research and revolutionized light microscopy by opening the door to the visualization of cellular structures in unprecedented detail.

Among many prizes, Stefan Hell received the Nobel Price in Chemistry 2014. Since then, he and his fellow colleagues have not rested and pushed the achievable resolution to the molecular scale with MINFLUX. This microscope can discern molecules even if they are just one nanometer apart, and they can track their position hundred times faster than before.

Facts aside, of course, we at abberior know all of this, since we have the privilege of looking through these spectacular instruments every day when we build, develop, and market them. And so do our 100 employees in Europe, China, North America, and thousands of customers using our instruments all over the world.

In abberiors’ constant quest to provide researchers with revolutionary tools for high-quality confocal and super-resolution microscopy, we present our newest development: TIMEBOW lifetime imaging.

TIMEBOW provides a straightforward way to take advantage of the lifetime information that is carried by every photon from the sample. Instead of looking at intensity only, discarding this information, TIMEBOW exploits it and advances your imaging with and without super resolution. Within seconds, lifetime variabilities are turned into color-coded images, dyes become unmixed and resolution is increased.

In combination with our groundbreaking MATRIX array detector, TIMEBOW is especially powerful – TIMEBOW boosts the resolution and MATRIX removes the background. What more could you ask for?

2021 has been a tumultuous year for all of us, full of small and big adjustments. Despite the challenges, abberior can also look back at many exciting developments. With the year slowly coming to its and, we would like to take a moment to focus on what made 2021 matter.

We keep on breaking barriers: In our quest to continuously provide the world’s first-class resolution microscopy, we introduced MINFLUX 3D this year. This technology allows our MINFLUX platform to achieve single-digit nanometer resolution in all three spatial dimensions – a level that is unachievable by any other product on the market. Our assortment in dyes and labels has also been greatly expanded. Especially in the sector of live-cell microscopy and Long-Stokes shift, we advanced the toolkit for scientists by developing new fluorophores.

Innovation is the name of our game: This year we participated for the first time in the TOP 100 competition for innovation in German small and medium enterprises. After passing their test, a data driven performance analysis, we received the prestigious TOP 100 seal and even took second place in our size class. The German Physical Society honored us with their Award for Technology Transfer. The award highlights the work that goes into making an invention available.

Expanding in times of a pandemic: The coronavirus continued to dictate many aspects of our daily lives. Lots of energy and time were invested to create the safest possible work environment for our employees. While all this was happening, abberior surely did not stop growing. For example, this year saw the establishment of our second office in the USA and our first microscope being delivered to Russia. Special attention was given to the Chinese market: we established our first local office with service and sales employees in Beijing and launched a custom Chinese website. Our central office in Göttingen kept growing as well, with our current facilities running out of space. Luckily, relief is on the horizon – literally – with our new headquarters starting development in a brand-new building right around the corner.

These days, team spirit and solidarity are especially important, and we are happy to have achieved so many great things together. And we will continue to do so in 2022, with many exciting things to come. But for now, we wish you and your loved ones a restful holiday season and a safe start into the New Year.

Technology Transfer Award of the German Physical Society

The German Physical Society (DPG) has awarded the Technology Transfer Prize to abberior, the Max Planck Institute for Biophysical Chemistry and Max Planck Innovation GmbH. The three institutions receive the prize for the successful industrial implementation of research results in the field of high-resolution light microscopy. The award recognizes the many steps that go into the realization of innovative discoveries into an entrepreneurial setting.

abberior emerged in the early 2010s from Stefan Hell’s NanoBiophotonics department at the MPI for Biophysical Chemistry. Max Planck Innovation GmbH, as a link between science and industry, accompanied the founding of the company and licensenewd out the findings in the field of fluorescence microscopy to the then start-up.

Gerald Donnert, our CEO, is delighted with the recognition and at the same time sets clear goals: “In the end, our microscopes are tools that can be used to make fundamental discoveries in biology and medicine that will benefit everyone in the future. At abberior Instruments, we want to provide researchers from around the world with the sharpest and most powerful fluorescence microscopes that can be built today. This advances industrial and academic research and helps to identify the systematics of disease or life on a molecular scale.”

Our main goal at abberior is to push beyond barriers with new discoveries and to make those discoveries accessible to scientists around the world. That in itself carries lots of innovative spirit. Add to that a skilled young team, a constant stream of new inventions and the ambitious energy of a start-up and you get one of the most innovative enterprises in Germany.

Now the winners of the prestigious TOP 100 award were announced in a virtual conference by mentor Ranga Yogeshwar. The innovation competition, which is being held for the 28th time, analyzed all applicants on the basis of more than 100 performance indicators in five categories before awarding the seal. Among companies of similar size abberior Instruments took the second place, with our particularly impressive performance in the category “Innovation Success” being highlighted.

The scientific management is organized by Prof. Dr. Nikolaus Franke. As founder and director of the Institute for Entrepreneurship and Innovation at the Vienna University of Economics and Business, Franke is one of the leading innovation researchers internationally. Project partners are the Fraunhofer Society for the Promotion of Applied Research and the BVMW association of small and medium-sized enterprises.

The managing group behind the building project holding trowels with concrete
The visitors of the event listening to Professor Stefan W. Hell giving his speech
Professor Stefan W. Hell standing in front of a banner by MBN Bau GmbH
The copper time capsule to commemorate the laying of the foundation
An overview of the building site with banners and scaffolding
Side view of abberior's new headquarter
Frontal view of abberior's new headquarter

It’s a new era for abberior. Last Friday, we celebrated the laying of the foundation of our new headquarters in Göttingen. The new building will be located in the direct vicinity of the researchers at the North Campus of the University of Göttingen and the Max-Planck-Institute for Biophysical Chemistry. As co-founder and Nobel prize winner Stefan W. Hell explained in his speech: “What better way for researchers at Göttingen University to know that the world’s sharpest microscopes are literally built a few hundred meters around the corner. Or that one or two phone calls are enough to be able to bring along a sample and make the crucial measurement for a research paper. You won’t find that anywhere else.”

The project is the result of a collaboration between our companies, the GWG, an investor for urban business development, the city of Göttingen and the University of Göttingen, who supplied the building area. In total, 14 million euros will be invested in the seven-story building to create research, production and office spaces for 200 employees. The building is planned to be finished in the second half of 2022. Not a day to soon, adds co-founder and CEO Dr. Gerald Donnert: “Currently, we hire 30 new people each year.”

Until then, we will keep you up to date with the progress on our social media pages (Twitter, Instagram, LinkedIn, Facebook). And while you’re at it: Why not have a look at our current job postings and save yourself a seat in our new headquarters?

Welcome to abberior's custom chinese site
Outside view of abberior's office in Beijing
Outside view of abberior's office in Beijing
Reception area of abberior's office in Beijing
Comfortable common room at abberior's office in Beijing
Common room at abberior's office in Beijing
Workspaces at abberior's office in Beijing
Window view at abberior's office in Beijing
Window view at abberior's office in Beijing

China is very important for us and for the world! We are proud to announce that abberior is actively expanding the Chinese market. Users around the world can now directly benefit from the “latest STED and MINFLUX systems with the highest spatial resolution in fluorescence microscopy”, as Prof. Stefan W. Hell stated.

abberior has opened the first office in Beijing and is looking forward to welcoming guests. Here, our experienced scientists and engineers will give customers vivid system presentations and demonstrations on site or remotely.

To make access to our technology as easy as possible, we launched our Chinese website today. With just a few clicks, scientists and researchers can find key product information, learn how they can benefit from patented abberior technologies, have all company news at their fingertips, and get direct access to local technical support.

We are convinced that direct and barrier-free communication with our customers, strengthens mutual trust and cooperation and will be a guarantee for future success on both sides.

MINFLUX microscope at EMBL imaging centre up-close
abberior's technicians installing MINFLUX at EMBL Imaging Centre

abberior and the European Molecular Biology Laboratory (EMBL) have launched a collaboration on the application of MINFLUX in biology. The goal of this agreement is to combine forces regarding further development of the method, and to apply superresolution MINFLUX microscopy to living systems.

To this end, abberior installed a MINFLUX system at the EMBL Imaging Centre in Heidelberg, Germany in August 2020. This nanoscope will be used for developing imaging workflows and for targeting a broad range of biological questions. After successful proof-of-concept applications, the system will also be available for external users in the framework of the new EMBL Imaging Centre.

“This collaboration will allow us to apply MINFLUX to highly relevant questions in biology and to push the limits of this technology. In the near future, we will to adapt MINFLUX microscopy to operate in living systems.” said Christian Wurm, Head of the abberior application team.

The abberior MINFLUX system is the newest addition to the abberior product portfolio. It is the first commercialized microscopy system that provides true molecule-size resolution and holds the world-record in temporal resolution for single particle tracking.

 

Working on a FACILITY STED microscope at abberior's office in Bethesda
Kitchen area of abberior's office in Bethesda
Scientists working on a STEDYCON microscope at abberior's office in Bethesda
Conference space at abberior's office in Bethesda

Abberior has opened its new office in Bethesda, Maryland, USA. The new site houses conference and showrooms, demo rooms and offices, as well as a supply for replacement parts.

“Abberior Instruments America is excited to have opened our new office in Bethesda Maryland located less than 1 mile from the National Institutes of Health main campus and within a short drive of key research centers at Johns Hopkins and Howard Hughes’ Janelia Farms.” says David Melton, CEO of Abberior Instruments America.

Our US staff and two microscopes, a FACILITY line and a STEDYCON, are looking forward to our customers, many interesting discussions, live and remote demos, and exceptional images.

Professor Christian Eggeling working with a STEDYCON for his new publication on HIV

Using an abberior STED-FCS, a team from four European countries, comprising Christian Eggeling (Leibniz IPHT & Friedrich Schiller University Jena) and Delphine Muriaux (Montpellier Infectious Disease Research Institute) discovered the existence and composition of a lipid-based platform for HIV virus assembly. These results provide novel molecular insights on HIV virus assembly and are a starting point for the development of new antiviral drugs.

 

Read here: “HIV-1 Gag specifically restricts PI(4,5)P2 and cholesterol mobility in living cells creating a nanodomain platform for virus assembly”Science Advances

Rows of pipettes and droplets on the title cover of the science journal Max-Planck-Forschung 2020

In this article, Prof. Stefan Hell talks about his professional career, how he came to develop STED microscopy in the early nineties, and how our company was started and where it’s heading.

It’s a fantastic read about the early times of superresolution all the way up to now, with many interesting details about why things unfolded in a particular way. Don’t miss it if you’re interested in the history of STED, abberior, or Stefan Hell!

 

Further Information:
Website Max Planck
Full Article (German)

Scientists in France have successfully used an abberior STED system and abberior dyes to shoot images of SARS-CoV2 (“Corona”, magenta) infecting VeroE6 cells.

Understanding the precise structure of this virus and the processes during and after infection are crucial to finding a cure or vaccine, ending lockdowns all around the world. Standard light microscopes are not of much help, since they are limited by diffraction (approx. 200 nm), while the virus particles have a much smaller diameter at about 100 nm. Because of this, SARS-CoV2 and important cellular structures that it attacks only show up blurry in standard, e.g. so-called confocal microscopes.

In the past, electron microscopy would have been used, but sample preparation for this instruments in tedious and they cannot image living matter, which is nevertheless vital to unraveling the workings of a corona infection on the cellular level. This is where STED microscopy comes into play: with a resolution 5-10 times below the diffraction limit, and much weaker constraints regarding sample preparation, it’s going to be an important tool for finding drugs against corona and similar viruses.

 

Copyright: MDVA team/CNRS Montpellier, France (D. Muriaux, C. Favard, M.-P. Blanchard @MRI)

Abberior, the leading STED solution provider from the inventors of STED and Nikon Instruments Inc., innovator of advanced microscope systems today announced a strategic partnership to accelerate adoption of easy-to-use STED technology in the US. As part of this collaboration, abberior’s compact STEDYCON system will be distributed by Nikon.

Inquiries for Abberior Instruments America: David Melton | CEO | 561.972.9300 | info@abberior-instruments-america.com

Media Inquiries for Nikon Instruments Inc.: Kristina Corso | Communications Specialist | 212.931.6189 | kcorso@hotpaperlantern.com

Further Information

 

When we started our business in 2012 in a small office ‘garage’ in Göttingen, our vision was to become the technically leading manufacturer for superresolution microscopes worldwide. With currently around 50 employees in Heidelberg (Germany), Jupiter (Florida, USA) as well as in Basel (Switzerland), we have turned into a globally recognized maker of superresolution light microscopes, selling in more than 35 countries. Due to the excellence of our highly selected and skilled team we have been able to grow with remarkable speed, and now we’re officially recognized as a growth champion!

With fourth place in the category “manufacturing industry”*, and ranked number 133th of 500 companies nationwide, we are very proud to be part of the “Wachstumschampions 2019”. Our average growth between 2014 and 2017 was almost 60% per year.

The Focus ranking lists companies that have achieved the highest sales growth per year in the last three years. Statista sieved through thousands of companies with above-average growth from more than 2 million commercial register entries, and invited many more to apply for the 2019 Growth Championships. The companies now listed in the Focus magazine’s top list are the ones that received the “Growth Champion 2019” award.

 

Further Information

*without automobile, machinery and plant construction industry