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Science beyond Barriers

abberior instruments

Cell Biology

2022
PubMed

An extracellular receptor tyrosine kinase motif orchestrating intracellular STAT activation

Authors:

Xin Jin, Matthew Amoni, Guillaume Gilbert, Eef Dries, Rosa Doñate Puertas, Ashutosh Tomar, Chandan K Nagaraju, Ankit Pradhan, David I Yule, Tobie Martens, Roxane Menten, Pieter Vanden Berghe, Filip Rega, Karin Sipido, H Llewelyn Roderick

Keywords:

Human ventricle, Arrhythmia

Abstract:

Dysregulated intracellular Ca2+ handling involving altered Ca2+ release from intracellular stores via RyR channels underlies both arrhythmias and reduced function in heart failure (HF). Mechanisms linking RyR dysregulation and disease are not fully established. Studies in animals support a role for InsP3 receptor Ca2+ channels (InsP3R) in pathological alterations in cardiomyocyte Ca2+ handling but whether these findings translate to the divergent physiology of human cardiomyocytes during heart failure is not determined. Using electrophysiological and Ca2+ recordings in human ventricular cardiomyocytes, we uncovered that Ca2+ release via InsP3Rs facilitated Ca2+ release from RyR and induced arrhythmogenic delayed after depolarisations and action potentials. InsP3R-RyR crosstalk was particularly increased in HF at RyR clusters isolated from the T-tubular network. Reduced SERCA activity in HF further facilitated the action of InsP3. Nanoscale imaging revealed co-localisation of InsP3Rs with RyRs in the dyad, which was increased in HF, providing a mechanism for augmented Ca2+ channel crosstalk. Notably, arrhythmogenic activity dependent on InsP3Rs was increased in tissue wedges from failing hearts perfused with AngII to promote InsP3 generation. These data indicate a central role for InsP3R-RyR Ca2+ signalling crosstalk in the pro-arrhythmic action of GPCR agonists elevated in HF and the potential for their therapeutic targeting.

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