Products

Superresolution & Confocal Systems

  • Overview
  • MINFLUX
  • INFINITY
  • FACILITY
  • STEDYCON

Superresolution & Confocal Modules

  • Overview
  • MATRIX Detector
  • TIMEBOW Imaging
  • Adaptive Illumination
  • Adaptive Optics
  • EASY3D
  • RAINBOW Detection
  • STED Lasers
  • Autoalignment
  • Autofocus
  • Excitation Lasers
  • Accessories
  • Custom Solutions

Dyes & Labels

  • Overview
  • abberior STAR
  • abberior LIVE
  • abberior FLUX
  • abberior CAGE
  • abberior Supplies

Shop

  • Dyes by Product Name
  • Dyes by Technique
  • Dyes by Function
  • Microscopy Supplies

Applications

  • Overview
  • Live Cell Imaging
  • Cell Biology
  • Neurobiology
  • Virology
  • Microbiology
  • Zoology
  • Plant Sciences
  • Biophysics
  • Physiology
  • Membrane Biology
  • Material Science
  • All-purpose
  • Tailor-Made

Company

  • People
  • Founders
  • Mission
  • Career
  • Locations

News & Events

  • News
  • Events
  • Webinars
  • Past Events

Expertise

  • Knowledge Base
  • FAQ Videos
  • FAQ
  • Publications
  • White Papers
  • Sample Gallery
  • Microscopy Tutorials
  • Webinar Recordings
  • Protocols
  • Support
  • Contact
  • Shop
  • Search
  • EN
    中文
    Language
@abberior.rocks
MENU Contact
ready to useReady to use MINFLUX 3D
Science beyond Barriers

abberior dyes & labels

Neurobiology

2022
Journal of Extracellular Vesicles

Release of VAMP5-positive extracellular vesicles by retinal Müller glia in vivo

Authors:

Demais, V., Pohl, A., Wunderlich, K.A., Pfaller, A.M., Kaplan, L., Barthélémy, A., Dittrich, R., Puig, B., Giebel, B., Hauck, S.M., Pfrieger, F.W., Grosche, A.

Abstract:

Cell-cell interactions in the central nervous system are based on the release of molecules mediating signal exchange and providing structural and trophic support through vesicular exocytosis and the formation of extracellular vesicles. The specific mechanisms employed by each cell type in the brain are incompletely understood. Here, we explored the means of communication used by Müller cells, a type of radial glial cells in the retina, which forms part of the central nervous system. Using immunohistochemical, electron microscopic, and molecular analyses, we provide evidence for the release of distinct extracellular vesicles from endfeet and microvilli of retinal Müller cells in adult mice in vivo. We identify VAMP5 as a Müller cell-specific SNARE component that is part of extracellular vesicles and responsive to ischemia, and we reveal differences between the secretomes of immunoaffinity-purified Müller cells and neurons in vitro. Our findings suggest extracellular vesicle-based communication as an important mediator of cellular interactions in the retina.

< Back to publications
Full article >
linkedin facebook twitter Instagram

World+49 551 9995 4010USA+1 301 661 0078

© 2023 abberior

Superresolution & Confocal Systems

  • Overview
  • MINFLUX
  • INFINITY
  • FACILITY
  • STEDYCON

Superresolution & Confocal Modules

  • Overview
  • MATRIX Detector
  • TIMEBOW Imaging
  • Adaptive Illumination
  • Adaptive Optics
  • EASY3D
  • RAINBOW Detection
  • STED Lasers
  • Autoalignment
  • Autofocus
  • Excitation Lasers
  • Accessories
  • Custom Solutions

Dyes & Labels

  • Overview
  • abberior STAR
  • abberior LIVE
  • abberior FLUX
  • abberior CAGE
  • abberior Supplies

Shop

  • Dyes by Product Name
  • Dyes by Technique
  • Dyes by Function
  • Microscopy Supplies

Applications

  • Overview
  • Live Cell Imaging
  • Cell Biology
  • Neurobiology
  • Virology
  • Microbiology
  • Zoology
  • Plant Sciences
  • Biophysics
  • Physiology
  • Membrane Biology
  • Material Science
  • All-purpose
  • Tailor-Made

Company

  • People
  • Founders
  • Mission
  • Career
  • Locations

News & Events

  • News
  • Events
  • Webinars
  • Past Events

Expertise

  • Knowledge Base
  • FAQ Videos
  • FAQ
  • Publications
  • White Papers
  • Sample Gallery
  • Microscopy Tutorials
  • Webinar Recordings
  • Protocols
abberior instruments GmbH:
  • Imprint
  • Privacy Policy
  • Terms of Sale
abberior GmbH:
  • Imprint
  • Privacy Policy
  • Terms of Sale
Abberior Instruments America LLC:
  • Privacy Policy
  • Terms of use USA
  • contact
  • manuals
  • service
  • shop

Cookie settings

Please select whether this page may use cookies. Technically necessary cookies are always set. You can also find further information in our data protection statement.

These cookies are required to enable the basic functions of this website, we set a cookie accordingly. This saves your individual consent to the use of technically necessary cookies. Our website only uses technically necessary cookies.


Privacy PolicyImprint