Products

Superresolution & Confocal Systems

  • Overview
  • MINFLUX
  • INFINITY
  • FACILITY
  • STEDYCON

Superresolution & Confocal Modules

  • Overview
  • MATRIX Detector
  • TIMEBOW Imaging
  • Adaptive Illumination
  • Adaptive Optics
  • EASY3D
  • RAINBOW Detection
  • STED Lasers
  • Autoalignment
  • Autofocus
  • Excitation Lasers
  • Accessories
  • Custom Solutions

Dyes & Labels

  • Overview
  • abberior STAR
  • abberior LIVE
  • abberior FLUX
  • abberior CAGE
  • abberior Supplies

Shop

  • Dyes by Product Name
  • Dyes by Technique
  • Dyes by Function
  • Microscopy Supplies

Applications

  • Overview
  • Live Cell Imaging
  • Cell Biology
  • Neurobiology
  • Virology
  • Microbiology
  • Zoology
  • Plant Sciences
  • Biophysics
  • Physiology
  • Membrane Biology
  • Material Science
  • All-purpose
  • Tailor-Made

Company

  • People
  • Founders
  • Mission
  • Career
  • Locations

News & Events

  • News
  • Events
  • Webinars
  • Past Events

Expertise

  • Knowledge Base
  • FAQ Videos
  • FAQ
  • Publications
  • White Papers
  • Sample Gallery
  • Microscopy Tutorials
  • Webinar Recordings
  • Protocols
  • Support
  • Contact
  • Shop
  • Search
  • EN
    中文
    Language
@abberior.rocks
MENU Contact
ready to useReady to use MINFLUX 3D
Science beyond Barriers

abberior instruments

Tailor-Made

2021
Scientific reports

Predicting the membrane permeability of organic fluorescent probes by the deep neural network based lipophilicity descriptor DeepFl-LogP

Authors:

Soliman, K., Grimm, F., Wurm, C. A., & Egner, A.

Keywords:

Cheminformatics, Imaging techniques

Abstract:

Light microscopy has become an indispensable tool for the life sciences, as it enables the rapid acquisition of three-dimensional images from the interior of living cells/tissues. Over the last decades, super-resolution light microscopy techniques have been developed, which allow a resolution up to an order of magnitude higher than that of conventional light microscopy. Those techniques require labelling of cellular structures with fluorescent probes exhibiting specific properties, which are supplied from outside and therefore have to surpass cell membranes. Currently, major efforts are undertaken to develop probes which can surpass cell membranes and exhibit the photophysical properties required for super-resolution imaging. However, the process of probe development is still based on a tedious and time consuming manual screening. An accurate computer based model that enables the prediction of the cell permeability based on their chemical structure would therefore be an invaluable asset for the development of fluorescent probes. Unfortunately, current models, which are based on multiple molecular descriptors, are not well suited for this task as they require high effort in the usage and exhibit moderate accuracy in their prediction. Here, we present a novel fragment based lipophilicity descriptor DeepFL-LogP, which was developed on the basis of a deep neural network. DeepFL-LogP exhibits excellent correlation with the experimental partition coefficient reference data (R2 = 0.892 and MSE = 0.359) of drug-like substances. Further a simple threshold permeability model on the basis of this descriptor allows to categorize the permeability of fluorescent probes with 96% accuracy. This novel descriptor is expected to largely simplify and speed up the development process for novel cell permeable fluorophores.

< Back to publications
Full article >
linkedin facebook twitter Instagram

World+49 551 9995 4010USA+1 301 661 0078

© 2023 abberior

Superresolution & Confocal Systems

  • Overview
  • MINFLUX
  • INFINITY
  • FACILITY
  • STEDYCON

Superresolution & Confocal Modules

  • Overview
  • MATRIX Detector
  • TIMEBOW Imaging
  • Adaptive Illumination
  • Adaptive Optics
  • EASY3D
  • RAINBOW Detection
  • STED Lasers
  • Autoalignment
  • Autofocus
  • Excitation Lasers
  • Accessories
  • Custom Solutions

Dyes & Labels

  • Overview
  • abberior STAR
  • abberior LIVE
  • abberior FLUX
  • abberior CAGE
  • abberior Supplies

Shop

  • Dyes by Product Name
  • Dyes by Technique
  • Dyes by Function
  • Microscopy Supplies

Applications

  • Overview
  • Live Cell Imaging
  • Cell Biology
  • Neurobiology
  • Virology
  • Microbiology
  • Zoology
  • Plant Sciences
  • Biophysics
  • Physiology
  • Membrane Biology
  • Material Science
  • All-purpose
  • Tailor-Made

Company

  • People
  • Founders
  • Mission
  • Career
  • Locations

News & Events

  • News
  • Events
  • Webinars
  • Past Events

Expertise

  • Knowledge Base
  • FAQ Videos
  • FAQ
  • Publications
  • White Papers
  • Sample Gallery
  • Microscopy Tutorials
  • Webinar Recordings
  • Protocols
abberior instruments GmbH:
  • Imprint
  • Privacy Policy
  • Terms of Sale
abberior GmbH:
  • Imprint
  • Privacy Policy
  • Terms of Sale
Abberior Instruments America LLC:
  • Privacy Policy
  • Terms of use USA
  • contact
  • manuals
  • service
  • shop

Cookie settings

Please select whether this page may use cookies. Technically necessary cookies are always set. You can also find further information in our data protection statement.

These cookies are required to enable the basic functions of this website, we set a cookie accordingly. This saves your individual consent to the use of technically necessary cookies. Our website only uses technically necessary cookies.


Privacy PolicyImprint