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Science beyond Barriers

abberior dyes & labels

2016
EMBO reports

High density of REC 8 constrains sister chromatid axes and prevents illegitimate synaptonemal complex formation

Authors:

Agostinho, A., Manneberg, O., van Schendel, R., Hernández‐Hernández, A., Kouznetsova, A., Blom, H., ... & Höög, C.

Keywords:

cohesin, meiosis, sister chromatid cohesion, super-resolution microscopy, synaptonemal complex

Abstract:

During meiosis, cohesin complexes mediate sister chromatid cohesion (SCC), synaptonemal complex (SC) assembly and synapsis. Here, using super-resolution microscopy, we imaged sister chromatid axes in mouse meiocytes that have normal or reduced levels of cohesin complexes, assessing the relationship between localization of cohesin complexes, SCC and SC formation. We show that REC8 foci are separated from each other by a distance smaller than 15% of the total chromosome axis length in wild-type meiocytes. Reduced levels of cohesin complexes result in a local separation of sister chromatid axial elements (LSAEs), as well as illegitimate SC formation at these sites. REC8 but not RAD21 or RAD21L cohesin complexes flank sites of LSAEs, whereas RAD21 and RAD21L appear predominantly along the separated sister-chromatid axes. Based on these observations and a quantitative distribution analysis of REC8 along sister chromatid axes, we propose that the high density of randomly distributed REC8 cohesin complexes promotes SCC and prevents illegitimate SC formation.

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