Endosomal lipid signaling reshapes the endoplasmic reticulum to control mitochondrial function

Authors:

Wonyul Jang, Dmytro Puchkov, Paula Samsó, YongTian Liang, Michal Nadler-Holly, Stephan J. Sigrist, Ulrich Kintscher, Fan Liu, Kamel Mamchaoui, Vincent Mouly, Volker Haucke

Keywords:

Vesicle Trafficing, Endoplasmatic Recticulum, Mitochondria

Abstract:

Nutrient starvation triggers changes in metabolism that are coordinated across the cell and its organelles. Jang et al. studied how endosomal signaling lipid turnover through MTM1, a phosphoinositide 3-phosphatase mutated in X-linked centronuclear myopathy in humans, reshapes the endoplasmic reticulum to control mitochondrial morphology and oxidative metabolism (see the Perspective by Zanellati and Cohen). A lipid-controlled organellar relay transmits nutrient-triggered changes in endosomal signaling lipid levels to mitochondria to enable metabolic rewiring. —SMH

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