Products

Superresolution & Confocal Systems

  • Overview
  • MINFLUX
  • MIRAVA POLYSCOPE
  • INFINITY
  • FACILITY
  • STEDYCON
  • Software Overview
  • LiGHTBOX
  • STEDYCON smart control
  • iMSPECTOR

Superresolution & Confocal Modules

  • Overview
  • MINFLUX Module
  • MATRIX Detector
  • TIMEBOW Imaging
  • FLEXPOSURE Illumination
  • RAYSHAPE Mirror
  • TRUESHARP Deconvolution
  • EASY3D
  • RAINBOW Detection
  • STED Lasers
  • Autoalignment
  • Autofocus
  • Excitation Lasers
  • Accessories
  • Custom Solutions

Dyes & Labels

  • Overview
  • abberior STAR
  • abberior LIVE
  • abberior FLUX
  • abberior CAGE
  • abberior Supplies

Shop

  • Dyes by Product Name
  • Dyes by Technique
  • Dyes by Label
  • Mounting Medium
  • Cells and Nanoparticles

Applications

  • Overview
  • Biophysics
  • Cell Biology
  • Live Cell Imaging
  • Material Science
  • Membrane biology
  • Microbiology
  • Neurobiology
  • Physiology
  • Plant Science
  • Virology
  • Zoology

Company

  • People
  • Founders
  • Mission
  • Career
  • Vacancies
  • Locations

News & Events

  • News
  • Events
  • Webinars
  • Past Events

Expertise

  • Knowledge Base
  • FAQ Videos
  • FAQ
  • Publications
  • White Papers
  • Sample Gallery
  • Microscopy Tutorials
  • Webinar Recordings
  • Protocols
  • Support
  • Contact
  • Shop
  • Search
  • EN
    中文
    Language
@abberior.rocks
MENU Contact
MIRAVA POLYSCOPE – All in one and on for all: the perfect image
Science beyond Barriers

abberior instruments

Material Science

2023
Journal of Molecular Liquids

Different implantable electrospun meshes for simultaneous application of prednisone and doxorubicin

Authors:

Krisztina Toth, Nora Fekete, Vivien Klaudia Simon, Bence Toth, Arpad Ferenc Koacs, Èva Pallinger, Istvan Kohidai, Angela Jedlovszky-Hajdu, David Juriga, Krisztina S. Nagy

Keywords:

Electrospinning, Poly(vinyl alcohol), Polycaprolactone, Polysuccinimide, Doxorubicin, Nanofiber meshes, Drug delivery

Abstract:

Electrospinning is widely applied to prepare nanofibers that provide high specific surfaces, enhanced bioavailability of poorly water-soluble drugs, moreover, enable several administration routes such as implantation. In this perspective, biocompatible poly(vinyl alcohol) (PVA), polysuccinimide (PSI), and ε-polycaprolactone (PCL) based implantable scaffolds were developed by electrospinning to improve the bioavailability of incorporated or conjugated prednisone (Pred) and doxorubicin (Dox). Besides physicochemical characterization, the effect of the loaded amount of Prednisone on the mechanical properties of the fibers as well as their drug release profile were investigated. The drug release measurement revealed that the release profile highly depends on the polarity of the applied polymer as well as the environmental pH. Concerning electrospun meshes incorporating prednisone, the anti-inflammatory effect was monitored by measuring the release of a wide spectrum of cytokines by MDA-MB-231 cells. Besides the loading of doxorubicin, the chemical conjugation to polysuccinimide was successfully carried out which provided prolonged release as well as increased cellular uptake. Based on the different drug release profiles, poly(vinyl alcohol), polysuccinimide, and ε-polycaprolactone fibrous meshes can be used to prepare a potential multi-layered drug-containing implantable scaffold, which can provide both burst and prolonged release of prednisone and doxorubicin. The anti-inflammatory effect of prednisone could be beneficial to avoid rejection after implantation while incorporation or conjugation of doxorubicin into polysuccinimide fibers provides sufficient cytotoxicity and enhanced cellular uptake of MDA-MB-231 cells.

< Back to publications
Full article >
linkedin facebook bluesky twitter Instagram

World+49 551 9995 4010USA+1 301 661 0078

© 2025 abberior

Superresolution & Confocal Systems

  • Overview
  • MINFLUX
  • MIRAVA POLYSCOPE
  • INFINITY
  • FACILITY
  • STEDYCON
  • Software Overview
  • LiGHTBOX
  • STEDYCON smart control
  • iMSPECTOR

Superresolution & Confocal Modules

  • Overview
  • MINFLUX Module
  • MATRIX Detector
  • TIMEBOW Imaging
  • FLEXPOSURE Illumination
  • RAYSHAPE Mirror
  • TRUESHARP Deconvolution
  • EASY3D
  • RAINBOW Detection
  • STED Lasers
  • Autoalignment
  • Autofocus
  • Excitation Lasers
  • Accessories
  • Custom Solutions

Dyes & Labels

  • Overview
  • abberior STAR
  • abberior LIVE
  • abberior FLUX
  • abberior CAGE
  • abberior Supplies

Shop

  • Dyes by Product Name
  • Dyes by Technique
  • Dyes by Label
  • Mounting Medium
  • Cells and Nanoparticles

Applications

  • Overview
  • Biophysics
  • Cell Biology
  • Live Cell Imaging
  • Material Science
  • Membrane biology
  • Microbiology
  • Neurobiology
  • Physiology
  • Plant Science
  • Virology
  • Zoology

Company

  • People
  • Founders
  • Mission
  • Career
  • Vacancies
  • Locations

News & Events

  • News
  • Events
  • Webinars
  • Past Events

Expertise

  • Knowledge Base
  • FAQ Videos
  • FAQ
  • Publications
  • White Papers
  • Sample Gallery
  • Microscopy Tutorials
  • Webinar Recordings
  • Protocols
abberior instruments GmbH:
  • Imprint
  • Privacy Policy
  • Terms of Sale
abberior GmbH:
  • Imprint
  • Privacy Policy
  • Terms of Sale
Abberior Instruments America LLC:
  • Privacy Policy
  • Terms of use USA
  • contact
  • manuals
  • service
  • shop