abberior instruments
2024
Nature Communications
An elevated rate of whole-genome duplications in cancers from Black patients
Authors:
Leanne M. Brown, Ryan A. Hagenson, Tilen Koklič, Iztok Urbančič, Lu Qiao, Janez Strancar, Jason M. Sheltzer
Keywords:
Aneuploidy; Cancer genomics; Genomic instability; Tumour heterogeneity; whole-genome duplications
Abstract:
In the United States, Black individuals have higher rates of cancer mortality than any other racial group. Here, we examine chromosome copy number changes in cancers from more than 1800 self-reported Black patients. We find that tumors from self-reported Black patients are significantly more likely to exhibit whole-genome duplications (WGDs), a genomic event that enhances metastasis and aggressive disease, compared to tumors from self-reported white patients. This increase in WGD frequency is observed across multiple cancer types, including breast, endometrial, and lung cancer, and is associated with shorter patient survival. We further demonstrate that combustion byproducts are capable of inducing WGDs in cell culture, and cancers from self-reported Black patients exhibit mutational signatures consistent with exposure to these carcinogens. In total, these findings identify a type of genomic alteration that is associated with environmental exposures and that may influence racial disparities in cancer outcomes.