The evolution of the Puf superfamily of proteins across the tree of eukaryotes
Najdrová, V., Stairs, C. W., Vinopalová, M., Voleman, L., & Doležal, P.
RNA-binding protein, RNA processing, LECA, Puf superfamily proteins, Giardia intestinalis
Eukaryotic gene expression is controlled by a number of RNA-binding proteins (RBP), such as the proteins from the Puf (Pumilio and FBF) superfamily (PufSF). These proteins bind to RNA via multiple Puf repeat domains, each of which specifically recognizes a single RNA base. Recently, three diversified PufSF proteins have been described in model organisms, each of which is responsible for the maturation of ribosomal RNA or the translational regulation of mRNAs; however, less is known about the role of these proteins across eukaryotic diversity.