Rhodamines NN: a novel class of caged fluorescent dyes

Authors:

Belov, V. N., Wurm, C. A., Boyarskiy, V. P., Jakobs, S., & Hell, S. W.

Keywords:

caged compounds, diazo compounds, fluorescence, imaging agents, rhodamines

Abstract:

A bright future: The reaction of diazomethane with acid chlorides obtained from N,N,N′,N′-tetraalkylrhodamines affords 2-diazo-2,3-dihydro-1H-indenespiro[1,9′]-9H-xanthen-3-ones—a novel class of caged rhodamines. These dyes allow new imaging procedures based on the step-wise activation and detection of several fluorescent markers (see picture).

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