Products

Superresolution & Confocal Systems

  • Overview
  • MINFLUX
  • INFINITY
  • FACILITY
  • STEDYCON

Superresolution & Confocal Modules

  • Overview
  • MATRIX Detector
  • TIMEBOW Imaging
  • Adaptive Illumination
  • Adaptive Optics
  • EASY3D
  • RAINBOW Detection
  • STED Lasers
  • Autoalignment
  • Autofocus
  • Excitation Lasers
  • Accessories
  • Custom Solutions

Dyes & Labels

  • Overview
  • abberior STAR
  • abberior LIVE
  • abberior FLUX
  • abberior CAGE
  • abberior Supplies

Shop

  • Dyes by Product Name
  • Dyes by Technique
  • Dyes by Function
  • Microscopy Supplies

Applications

  • Overview
  • Live Cell Imaging
  • Cell Biology
  • Neurobiology
  • Virology
  • Microbiology
  • Zoology
  • Plant Sciences
  • Biophysics
  • Physiology
  • Membrane Biology
  • Material Science
  • All-purpose
  • Tailor-Made

Company

  • People
  • Founders
  • Mission
  • Career
  • Locations

News & Events

  • News
  • Events
  • Webinars
  • Past Events

Expertise

  • Knowledge Base
  • FAQ Videos
  • FAQ
  • Publications
  • White Papers
  • Sample Gallery
  • Microscopy Tutorials
  • Webinar Recordings
  • Protocols
  • Support
  • Contact
  • Shop
  • Search
  • EN
    中文
    Language
@abberior.rocks
MENU Contact
ready to useReady to use MINFLUX 3D
Science beyond Barriers

abberior instruments

Cell Biology

2021
Nucleic Acids Research

Conservation and divergence of meiotic DNA double strand break forming mechanisms in Arabidopsis thaliana

Authors:

Vrielynck, N., Schneider, K., Rodriguez, M., Sims, J., Chambon, A., Hurel, A., ... & Grelon, M.

Keywords:

Genome integrity, repair and replication

Abstract:

In the current meiotic recombination initiation model, the SPO11 catalytic subunits associate with MTOPVIB to form a Topoisomerase VI-like complex that generates DNA double strand breaks (DSBs). Four additional proteins, PRD1/AtMEI1, PRD2/AtMEI4, PRD3/AtMER2 and the plant specific DFO are required for meiotic DSB formation. Here we show that (i) MTOPVIB and PRD1 provide the link between the catalytic sub-complex and the other DSB proteins, (ii) PRD3/AtMER2, while localized to the axis, does not assemble a canonical pre-DSB complex but establishes a direct link between the DSB-forming and resection machineries, (iii) DFO controls MTOPVIB foci formation and is part of a divergent RMM-like complex including PHS1/AtREC114 and PRD2/AtMEI4 but not PRD3/AtMER2, (iv) PHS1/AtREC114 is absolutely unnecessary for DSB formation despite having a conserved position within the DSB protein network and (v) MTOPVIB and PRD2/AtMEI4 interact directly with chromosome axis proteins to anchor the meiotic DSB machinery to the axis.

< Back to publications
Full article >
linkedin facebook twitter Instagram

World+49 551 9995 4010USA+1 301 661 0078

© 2023 abberior

Superresolution & Confocal Systems

  • Overview
  • MINFLUX
  • INFINITY
  • FACILITY
  • STEDYCON

Superresolution & Confocal Modules

  • Overview
  • MATRIX Detector
  • TIMEBOW Imaging
  • Adaptive Illumination
  • Adaptive Optics
  • EASY3D
  • RAINBOW Detection
  • STED Lasers
  • Autoalignment
  • Autofocus
  • Excitation Lasers
  • Accessories
  • Custom Solutions

Dyes & Labels

  • Overview
  • abberior STAR
  • abberior LIVE
  • abberior FLUX
  • abberior CAGE
  • abberior Supplies

Shop

  • Dyes by Product Name
  • Dyes by Technique
  • Dyes by Function
  • Microscopy Supplies

Applications

  • Overview
  • Live Cell Imaging
  • Cell Biology
  • Neurobiology
  • Virology
  • Microbiology
  • Zoology
  • Plant Sciences
  • Biophysics
  • Physiology
  • Membrane Biology
  • Material Science
  • All-purpose
  • Tailor-Made

Company

  • People
  • Founders
  • Mission
  • Career
  • Locations

News & Events

  • News
  • Events
  • Webinars
  • Past Events

Expertise

  • Knowledge Base
  • FAQ Videos
  • FAQ
  • Publications
  • White Papers
  • Sample Gallery
  • Microscopy Tutorials
  • Webinar Recordings
  • Protocols
abberior instruments GmbH:
  • Imprint
  • Privacy Policy
  • Terms of Sale
abberior GmbH:
  • Imprint
  • Privacy Policy
  • Terms of Sale
Abberior Instruments America LLC:
  • Privacy Policy
  • Terms of use USA
  • contact
  • manuals
  • service
  • shop

Cookie settings

Please select whether this page may use cookies. Technically necessary cookies are always set. You can also find further information in our data protection statement.

These cookies are required to enable the basic functions of this website, we set a cookie accordingly. This saves your individual consent to the use of technically necessary cookies. Our website only uses technically necessary cookies.


Privacy PolicyImprint